Xerostomic complaints induced by an anti-sialogogue in healthy young vs. older adults.
Identifieur interne : 000497 ( Main/Exploration ); précédent : 000496; suivant : 000498Xerostomic complaints induced by an anti-sialogogue in healthy young vs. older adults.
Auteurs : P S Patel [États-Unis] ; E M Ghezzi ; J A ShipSource :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 0275-1879 ]
Descripteurs français
- KwdFr :
- Adulte (MeSH), Antagonistes muscariniques (effets indésirables), Débit sécrétoire (effets des médicaments et des substances chimiques), Enquêtes et questionnaires (MeSH), Facteurs âges (MeSH), Femelle (MeSH), Glande parotide (métabolisme), Glycopyrronium (effets indésirables), Humains (MeSH), Loi du khi-deux (MeSH), Mâle (MeSH), Salivation (effets des médicaments et des substances chimiques), Sujet âgé (MeSH), Xérostomie (induit chimiquement).
- MESH :
- effets des médicaments et des substances chimiques : Débit sécrétoire, Salivation.
- effets indésirables : Antagonistes muscariniques, Glycopyrronium.
- induit chimiquement : Xérostomie.
- métabolisme : Glande parotide.
- Adulte, Enquêtes et questionnaires, Facteurs âges, Femelle, Humains, Loi du khi-deux, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- Adult (MeSH), Age Factors (MeSH), Aged (MeSH), Chi-Square Distribution (MeSH), Female (MeSH), Glycopyrrolate (adverse effects), Humans (MeSH), Male (MeSH), Muscarinic Antagonists (adverse effects), Parotid Gland (metabolism), Salivation (drug effects), Secretory Rate (drug effects), Surveys and Questionnaires (MeSH), Xerostomia (chemically induced).
- MESH :
- chemical , adverse effects : Glycopyrrolate, Muscarinic Antagonists.
- chemically induced : Xerostomia.
- drug effects : Salivation, Secretory Rate.
- metabolism : Parotid Gland.
- Adult, Age Factors, Aged, Chi-Square Distribution, Female, Humans, Male, Surveys and Questionnaires.
Abstract
Complaints of xerostomia and salivary hypofunction are common in older adults. However, recent studies reported that dehydration-induced salivary hypofunction caused fewer xerostomic complaints in older compared with young adults. This may predispose older adults to developing oral problems that will subsequently not receive attention from health care providers. Since many medications are known to inhibit salivation, this study attempted to determine if an anticholinergic drug (glycopyrrolate) had a differential effect on xerostomic complaints in young vs. older adults. Eighteen young (age 20-38 yrs) and 18 older (age 60-77 yrs) healthy adults were given a 4.0 micrograms/kg dose of i.v. glycopyrrolate. For 6 hrs after drug administration, stimulated parotid salivary flow was collected, and an eight-item Visual Analogue Scale (VAS) subjective xerostomia test was given. At several time points post-i.v. glycopyrrolate, salivary flow rates were consistently lower in older compared with young adults. For some measures of xerostomic complaint (time to first complaint; time to maximum complaint; mean maximum complaint), there were no age-related differences for all VAS items. However, a trend for increased xerostomic complaints in older adults was demonstrated (time to recovery; total duration of complaint; number xerostomic at 6 hrs). These findings suggest that, given equal doses of an anti-sialogogue, salivary hypofunction is greater in healthy older adults, while increased complaints of xerostomia are not as consistent.
DOI: 10.1111/j.1754-4505.2001.tb00251.x
PubMed: 11803641
Affiliations:
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(MeSH)</term><term>Muscarinic Antagonists (adverse effects)</term><term>Parotid Gland (metabolism)</term><term>Salivation (drug effects)</term><term>Secretory Rate (drug effects)</term><term>Surveys and Questionnaires (MeSH)</term><term>Xerostomia (chemically induced)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Antagonistes muscariniques (effets indésirables)</term><term>Débit sécrétoire (effets des médicaments et des substances chimiques)</term><term>Enquêtes et questionnaires (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Femelle (MeSH)</term><term>Glande parotide (métabolisme)</term><term>Glycopyrronium (effets indésirables)</term><term>Humains (MeSH)</term><term>Loi du khi-deux (MeSH)</term><term>Mâle (MeSH)</term><term>Salivation (effets des médicaments et des substances chimiques)</term><term>Sujet âgé (MeSH)</term><term>Xérostomie (induit chimiquement)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Glycopyrrolate</term><term>Muscarinic Antagonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Xerostomia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Salivation</term><term>Secretory Rate</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Débit sécrétoire</term><term>Salivation</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antagonistes muscariniques</term><term>Glycopyrronium</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Xérostomie</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parotid Gland</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glande parotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Male</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Enquêtes et questionnaires</term><term>Facteurs âges</term><term>Femelle</term><term>Humains</term><term>Loi du khi-deux</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Complaints of xerostomia and salivary hypofunction are common in older adults. However, recent studies reported that dehydration-induced salivary hypofunction caused fewer xerostomic complaints in older compared with young adults. This may predispose older adults to developing oral problems that will subsequently not receive attention from health care providers. Since many medications are known to inhibit salivation, this study attempted to determine if an anticholinergic drug (glycopyrrolate) had a differential effect on xerostomic complaints in young vs. older adults. Eighteen young (age 20-38 yrs) and 18 older (age 60-77 yrs) healthy adults were given a 4.0 micrograms/kg dose of i.v. glycopyrrolate. For 6 hrs after drug administration, stimulated parotid salivary flow was collected, and an eight-item Visual Analogue Scale (VAS) subjective xerostomia test was given. At several time points post-i.v. glycopyrrolate, salivary flow rates were consistently lower in older compared with young adults. For some measures of xerostomic complaint (time to first complaint; time to maximum complaint; mean maximum complaint), there were no age-related differences for all VAS items. However, a trend for increased xerostomic complaints in older adults was demonstrated (time to recovery; total duration of complaint; number xerostomic at 6 hrs). These findings suggest that, given equal doses of an anti-sialogogue, salivary hypofunction is greater in healthy older adults, while increased complaints of xerostomia are not as consistent.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11803641</PMID><DateCompleted><Year>2002</Year><Month>02</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0275-1879</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>5</Issue><PubDate><MedlineDate>2001 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>Xerostomic complaints induced by an anti-sialogogue in healthy young vs. older adults.</ArticleTitle><Pagination><MedlinePgn>176-81</MedlinePgn></Pagination><Abstract><AbstractText>Complaints of xerostomia and salivary hypofunction are common in older adults. However, recent studies reported that dehydration-induced salivary hypofunction caused fewer xerostomic complaints in older compared with young adults. This may predispose older adults to developing oral problems that will subsequently not receive attention from health care providers. Since many medications are known to inhibit salivation, this study attempted to determine if an anticholinergic drug (glycopyrrolate) had a differential effect on xerostomic complaints in young vs. older adults. Eighteen young (age 20-38 yrs) and 18 older (age 60-77 yrs) healthy adults were given a 4.0 micrograms/kg dose of i.v. glycopyrrolate. For 6 hrs after drug administration, stimulated parotid salivary flow was collected, and an eight-item Visual Analogue Scale (VAS) subjective xerostomia test was given. At several time points post-i.v. glycopyrrolate, salivary flow rates were consistently lower in older compared with young adults. For some measures of xerostomic complaint (time to first complaint; time to maximum complaint; mean maximum complaint), there were no age-related differences for all VAS items. However, a trend for increased xerostomic complaints in older adults was demonstrated (time to recovery; total duration of complaint; number xerostomic at 6 hrs). These findings suggest that, given equal doses of an anti-sialogogue, salivary hypofunction is greater in healthy older adults, while increased complaints of xerostomia are not as consistent.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>P S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Hospital Dentistry, State University of New York at Stony Brook, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghezzi</LastName><ForeName>E M</ForeName><Initials>EM</Initials></Author><Author ValidYN="Y"><LastName>Ship</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>D31AH90005</GrantID><Acronym>AH</Acronym><Agency>BHP HRSA HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DE07101</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 De00427</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>M01-RR00042</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018727">Muscarinic 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MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018727" MajorTopicYN="N">Muscarinic Antagonists</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010306" MajorTopicYN="N">Parotid Gland</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012472" MajorTopicYN="N">Salivation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012636" MajorTopicYN="N">Secretory Rate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014987" MajorTopicYN="N">Xerostomia</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>1</Month><Day>24</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>2</Month><Day>7</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>1</Month><Day>24</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11803641</ArticleId><ArticleId IdType="doi">10.1111/j.1754-4505.2001.tb00251.x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Ghezzi, E M" sort="Ghezzi, E M" uniqKey="Ghezzi E" first="E M" last="Ghezzi">E M Ghezzi</name><name sortKey="Ship, J A" sort="Ship, J A" uniqKey="Ship J" first="J A" last="Ship">J A Ship</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Patel, P S" sort="Patel, P S" uniqKey="Patel P" first="P S" last="Patel">P S Patel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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